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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3189 | B7/CD28 interaction inhibitor 1 | CTLA-4 inhibitor | Others |
B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor. | |||
T81329 | Quavonlimab | MK-1308 | |
Quavonlimab (MK-1308) is a novel antibody targeting CTLA-4 [1]. | |||
T77103 | Nurulimab | ||
Nurulimab (BCD-145) is a humanized monoclonal antibody targeting cytotoxic T lymphocyte antigen-4 (anti-CTLA-4). It has potential applications in melanoma research [1]. | |||
T76728 | Vudalimab | ||
Vudalimab, a fully humanized bispecific monoclonal antibody, effectively inhibits both PD-1 and CTLA-4 immune checkpoint receptors. This dual action facilitates the selective activation of T-cells targeting tumors. | |||
T77072 | Lorigerlimab | ||
Lorigerlimab (MGD019) is a bispecific IgG4 dual-affinity re-targeting (DART) antibody that blocks both PD-1 and CTLA-4, enhancing T-cell responses. It is under investigation for the treatment of metastatic castration-res... | |||
T80598 | Davoceticept | CD80 vIgD-Fc,ALPN-202 | |
Davoceticept (ALPN-202; CD80 vIgD-Fc), a monoclonal antibody that targets CTLA-4, is comprised of the (1-107) fragment of CD80 fused to the IGHG1 Fc domain through a peptidyl linker. It is commonly produced in CHO (Chine... | |||
T82268 | Gotistobart | BNT 316,ONC-392 | |
Gotistobart (ONC-392) is a humanized anti-CTLA-4 antibody that enhances immunotherapy by selectively depleting regulatory T cells (Treg) within the tumor microenvironment [1]. | |||
T76968 | Tuvonralimab | ||
Tuvonralimab (PSB-205; QL1706), comprising a combination of Iparomlimab and Tuvonralimab [1], functions as a dual immune checkpoint inhibitor through its formulation of anti-PD-1 IgG4 and anti-CTLA-4 IgG1 antibodies. | |||
T81124 | Sovipostobart | ||
Sovipostobart, an immunoglobulin G1-kappa monoclonal antibody targeting CTLA-4 in Homo sapiens, features a cleavable prodomain. This compound serves as both an immunostimulant and antineoplastic [1]. | |||
T76859 | Bavunalimab | ||
Bavunalimab (Anti-Human CTLA4xLAG3), a bispecific human monoclonal antibody targeting CTLA-4 and LAG-3, activates T cells in NSG mice and is utilized in cancer research [1]. | |||
T76933 | Botensilimab | ||
Botensilimab (AGEN 1181), a humanized monoclonal antibody targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4), functions as an activator of both innate and adaptive immunity. It is currently being researched for its pote... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05159 | Granzyme A/GZMA Protein, Human, Recombinant (His) | Human | HEK293 |
Granzyme A/GZMA Protein, Human, Recombinant (His) is expressed in HEK293 cells. | |||
TMPY-00817 | Granzyme B/GZMB Protein, Human, Recombinant (His) | Human | HEK293 |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the ... | |||
TMPJ-00770 | Granzyme B/GZMB Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an... | |||
TMPJ-00555 | B7-2 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | Human Cells |
The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T... | |||
TMPY-00818 | Granzyme H/GZMH Protein, Human, Recombinant (His) | Human | HEK293 |
Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes... | |||
TMPJ-00556 | B7-2 Protein, Human, Recombinant (His) | Human | Human Cells |
The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T... | |||
TMPY-02473 | ICOS Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPY-05156 | ICOS Protein, Human, Recombinant (rFc) | Human | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPY-04348 | CTLA-4 Protein, Human, Recombinant (His) | Human | HEK293 |
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands o... | |||
TMPY-04824 | CTLA-4 Protein, Human, Recombinant | Human | HEK293 |
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands o... | |||
TMPY-00674 | B7-1 Protein, Human, Recombinant | Human | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B c... | |||
TMPY-05079 | PD-1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-00996 | PD-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-05395 | PD-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-04898 | PD-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-05815 | PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated | Canine | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-00897 | PD-1 Protein, Human, Recombinant (His) | Human | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-04342 | PD-1 Protein, Canine, Recombinant (His) | Canine | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-05260 | PD-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-01604 | CTLA-4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands o... | |||
TMPK-00179 | B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated | Human | HEK293 |
Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligan... | |||
TMPK-00178 | B7-1 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligan... | |||
TMPY-03311 | ICOS Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPK-00882 | B7-2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the acti... | |||
TMPK-00880 | B7-2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the acti... | |||
TMPK-00881 | B7-2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the acti... | |||
TMPK-00086 | ICOS Protein, Human, Recombinant (aa 21-134, His) | Human | HEK293 |
Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. ... | |||
TMPK-00087 | ICOS Protein, Human, Recombinant (C136S & C137S, His) | Human | HEK293 |
Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. ... | |||
TMPY-04991 | ICOS Protein, Mouse, Recombinant (rFc) | Mouse | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPY-06979 | ICOS Protein, Human, Recombinant (His) | Human | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPJ-00640 | CTLA-4 Protein, Cavia porcellus, Recombinant (His) | Cavia porcellus | P. pastoris |
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the domina... | |||
TMPJ-00635 | CTLA-4 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | Human Cells |
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the domina... | |||
TMPJ-00636 | CTLA-4 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Human Cells |
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the domina... | |||
TMPY-01399 | ICOS Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPY-06209 | ICOS Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPY-05651 | ICOS Protein, Mouse, Recombinant (hFc & Avi), Biotinylated | Mouse | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPY-00461 | BTLA Protein, Rat, Recombinant (mFc) | Rat | HEK293 |
BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeuti... | |||
TMPY-05645 | ICOS Protein, Rhesus, Recombinant (hFc & Avi), Biotinylated | Rhesus | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPY-05174 | ICOS Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPY-05389 | ICOS Protein, Human, Recombinant (hFc) | Human | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, ... | |||
TMPJ-00958 | B7-1 Protein, Rabbit, Recombinant (His) | Rabbit | Human Cells |
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their recep... | |||
TMPJ-00107 | CTLA-4 Protein, Human, Recombinant (Flag) | Human | Human Cells |
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence... | |||
TMPJ-00108 | CTLA-4 Protein, Human, Recombinant (GST) | Human | Human Cells |
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence... | |||
TMPK-00653 | B7-2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the acti... | |||
TMPJ-00630 | B7-1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | Human Cells |
Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and... | |||
TMPY-06913 | BTLA Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeuti... | |||
TMPY-06922 | BTLA Protein, Human, Recombinant (isoform1, His) | Human | HEK293 |
BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeuti... | |||
TMPY-00175 | BTLA Protein, Human, Recombinant (hFc) | Human | HEK293 |
BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeuti... | |||
TMPY-06711 | B7-1 Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B c... | |||
TMPY-05811 | B7-1 Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B c... | |||
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